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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566110
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Clec1a
Name: C-type lectin domain family 1, member A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Clec1aincreases expressionISOClec1a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CLEC1A mRNAPMID:22610609
Clec1aincreases methylationISOCLEC1A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CLEC1A 3' UTR; Benzo(a)pyrene results in increased methylation of CLEC1A 5' UTR; Benzo(a)pyrene results in increased methylation of CLEC1A promoterPMID:27901495
Clec1amultiple interactionsISOClec1a (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CLEC1A mRNAPMID:27858113
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