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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgap36
Name: Rho GTPase activating protein 36
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arhgap36affects methylationISOARHGAP36 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ARHGAP36 5' UTR; Benzo(a)pyrene affects the methylation of ARHGAP36 exon; Benzo(a)pyrene affects the methylation of ARHGAP36 promoterPMID:27901495
Arhgap36increases expressionISOARHGAP36 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ARHGAP36 mRNAPMID:22316170
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