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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565818
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc8b1
Name: solute carrier family 8 member B1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc8b1decreases methylationISOSLC8B1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SLC8B1 3' UTRPMID:27901495
Slc8b1increases expressionISOSlc8b1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SLC8B1 mRNAPMID:22228805
Slc8b1increases methylationISOSLC8B1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SLC8B1 promoterPMID:27901495
Slc8b1increases methylationISOSlc8b1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of SLC8B1 exon; Benzo(a)pyrene results in increased methylation of SLC8B1 intronPMID:27901495
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