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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564507
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nckap5
Name: NCK-associated protein 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nckap5affects methylationISONCKAP5 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NCKAP5 5' UTR; Benzo(a)pyrene affects the methylation of NCKAP5 exon; Benzo(a)pyrene affects the methylation of NCKAP5 intronPMID:27901495 PMID:30157460
Nckap5decreases expressionISONCKAP5 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NCKAP5 mRNAPMID:32234424
Nckap5decreases methylationISONCKAP5 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of NCKAP5 promoterPMID:27901495
Nckap5multiple interactionsISONckap5 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to NCKAP5 promoter]PMID:19654925
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