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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563597
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dynlt2b
Name: dynein light chain Tctex-type 2B
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dynlt2baffects methylationISODYNLT2B (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DYNLT2B intronPMID:30157460
Dynlt2bdecreases methylationISODYNLT2B (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of DYNLT2B exon; Benzo(a)pyrene results in decreased methylation of DYNLT2B promoterPMID:27901495
Dynlt2bincreases expressionISODYNLT2B (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of DYNLT2B mRNAPMID:20106945 PMID:21632981
Dynlt2bmultiple interactionsISODynlt2b (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to DYNLT2B promoter]PMID:19654925
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