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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563022
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zfhx4
Name: zinc finger homeobox 4
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zfhx4affects methylationISOZFHX4 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ZFHX4 5' UTRPMID:27901495
Zfhx4decreases expressionISOZfhx4 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ZFHX4 mRNAPMID:19770486
Zfhx4increases expressionISOZFHX4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ZFHX4 mRNAPMID:22316170
Zfhx4increases methylationISOZFHX4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ZFHX4 promoterPMID:27901495
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