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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnik
Name: TRAF2 and NCK interacting kinase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnikaffects methylationISOTnik (Mus musculus)6480464CTDBenzo(a)pyrene affects the methylation of TNIK intronPMID:27901495
Tnikdecreases expressionISOTNIK (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of TNIK mRNAPMID:20064835 PMID:20106945
Tnikdecreases expressionISOTnik (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of TNIK mRNAPMID:19770486
Tnikincreases methylationISOTnik (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of TNIK exonPMID:27901495
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