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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr2c2ap
Name: nuclear receptor 2C2-associated protein
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr2c2apdecreases expressionISONr2c2ap (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of NR2C2AP mRNAPMID:19770486
Nr2c2apdecreases methylationISONR2C2AP (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of NR2C2AP 3' UTRPMID:27901495
Nr2c2apincreases expressionISONR2C2AP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of NR2C2AP mRNAPMID:32234424
Nr2c2apincreases expressionISONr2c2ap (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of NR2C2AP mRNAPMID:22228805
Nr2c2apincreases methylationISONR2C2AP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of NR2C2AP promoterPMID:27901495
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