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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560819
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chsy3
Name: chondroitin sulfate synthase 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chsy3affects methylationISOCHSY3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CHSY3 promoterPMID:27901495
Chsy3decreases expressionISOChsy3 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CHSY3 mRNAPMID:19770486
Chsy3increases methylationISOCHSY3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CHSY3 exonPMID:27901495
Chsy3increases mutagenesisISOCHSY3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of CHSY3 genePMID:25435355
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