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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560686
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sdk1
Name: sidekick cell adhesion molecule 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sdk1affects methylationISOSDK1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SDK1 intron; Benzo(a)pyrene affects the methylation of SDK1 polyA tail; Benzo(a)pyrene affects the methylation of SDK1 promoterPMID:27901495 PMID:30157460
Sdk1decreases expressionISOSDK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SDK1 mRNAPMID:21871943 PMID:32234424 PMID:35690182
Sdk1decreases expressionISOSdk1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SDK1 mRNAPMID:22228805
Sdk1decreases methylationISOSdk1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of SDK1 intronPMID:27901495
Sdk1increases mutagenesisISOSDK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of SDK1 genePMID:25435355
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