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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553420
Species: Mus musculus
RGD Object: Gene
Symbol: Prrx1
Name: paired related homeobox 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prrx1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of PRRX1 mRNAPMID:22610609
Prrx1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of PRRX1 exon; Benzo(a)pyrene results in increased methylation of PRRX1 intronPMID:27901495
Prrx1affects methylationISOPRRX1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PRRX1 intron; Benzo(a)pyrene affects the methylation of PRRX1 promoterPMID:27901495 PMID:30157460
Prrx1decreases expressionISOPRRX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PRRX1 mRNAPMID:22316170
Prrx1increases methylationISOPRRX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PRRX1 exonPMID:27901495
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