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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552182
Species: Mus musculus
RGD Object: Gene
Symbol: Pla2g3
Name: phospholipase A2, group III
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pla2g3increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of PLA2G3 mRNAPMID:27195522
Pla2g3multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to PLA2G3 promoter]PMID:19654925
Pla2g3affects methylationISOPLA2G3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PLA2G3 promoterPMID:27901495
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