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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551464
Species: Mus musculus
RGD Object: Gene
Symbol: Plscr2
Name: phospholipid scramblase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plscr2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of PLSCR2 mRNAPMID:15034205 PMID:19770486
Plscr2multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLSCR2 mRNA; AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of PLSCR2 mRNA]PMID:15034205 PMID:27858113
Plscr2affects methylationISOPLSCR2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PLSCR2 5' UTRPMID:27901495
Plscr2increases methylationISOPLSCR2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PLSCR2 promoterPMID:27901495
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