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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359547
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgdia
Name: Rho GDP dissociation inhibitor alpha
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arhgdiadecreases expressionISOARHGDIA (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ARHGDIA mRNAPMID:20106945
Arhgdiadecreases methylationISOARHGDIA (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ARHGDIA promoterPMID:27901495
Arhgdiaincreases expressionISOARHGDIA (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ARHGDIA proteinPMID:22138271
Arhgdiaincreases methylationISOARHGDIA (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ARHGDIA 3' UTR; Benzo(a)pyrene results in increased methylation of ARHGDIA 5' UTRPMID:27901495
Arhgdiamultiple interactionsISOARHGDIA (Homo sapiens)6480464CTDMethionine inhibits the reaction [Benzo(a)pyrene results in increased expression of ARHGDIA protein]PMID:22138271
Arhgdiamultiple interactionsISOArhgdia (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to ARHGDIA promoter]PMID:19654925
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