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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354301
Species: Homo sapiens
RGD Object: Gene
Symbol: ITM2A
Name: integral membrane protein 2A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ITM2Aaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of ITM2A 5' UTR; Benzo(a)pyrene affects the methylation of ITM2A exon; Benzo(a)pyrene affects the methylation of ITM2A promoterPMID:27901495
ITM2Aincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ITM2A mRNAPMID:32234424
ITM2Adecreases expressionISOItm2a (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ITM2A mRNAPMID:22228805
ITM2Aincreases expressionISOItm2a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ITM2A mRNAPMID:19770486
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