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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353629
Species: Homo sapiens
RGD Object: Gene
Symbol: IL12B
Name: interleukin 12B
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL12Baffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of IL12B promoterPMID:27901495
IL12Bdecreases expressionISOIl12b (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IL12B mRNAPMID:21569818
IL12Bmultiple interactionsISOIl12b (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with Lipopolysaccharides] results in increased expression of IL12B mRNAPMID:17275222
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