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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352349
Species: Homo sapiens
RGD Object: Gene
Symbol: CLDN2
Name: claudin 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CLDN2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of CLDN2 5' UTR; Benzo(a)pyrene affects the methylation of CLDN2 promoterPMID:27901495
CLDN2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CLDN2 mRNAPMID:32234424
CLDN2increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CLDN2 3' UTRPMID:27901495
CLDN2increases expressionISOCldn2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CLDN2 mRNAPMID:19770486 PMID:27195522
CLDN2multiple interactionsISOCldn2 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of CLDN2 mRNAPMID:26271895
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