GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HSPA1A | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of HSPA1A mRNA; Benzo(a)pyrene results in increased expression of HSPA1A protein | PMID:18495319 PMID:20106945 PMID:22316170 PMID:22367790 PMID:26238291 | HSPA1A | increases methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of HSPA1A exon; Benzo(a)pyrene results in increased methylation of HSPA1A promoter | PMID:27901495 | HSPA1A | multiple interactions | EXP | | 6480464 | CTD | HSPA1A gene SNP results in increased susceptibility to [[Coke results in increased abundance of Air Pollutants, Occupational] which results in increased abundance of Benzo(a)pyrene] | PMID:31730894 | HSPA1A | decreases expression | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of HSPA1A mRNA | PMID:27195522 | HSPA1A | increases expression | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of HSPA1A mRNA | PMID:15894712 PMID:21569818 | HSPA1A | multiple interactions | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA1A mRNA; [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HSPA1A mRNA; [Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of HSPA1A mRNA | PMID:15894712 PMID:26271895 PMID:27858113 | |
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