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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347094
Species: Homo sapiens
RGD Object: Gene
Symbol: IKBKG
Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IKBKGaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of IKBKG 5' UTR; Benzo(a)pyrene affects the methylation of IKBKG promoterPMID:27901495
IKBKGincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IKBKG mRNAPMID:22316170 PMID:26238291
IKBKGincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of IKBKG exonPMID:27901495
IKBKGincreases expressionISOIkbkg (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of IKBKG mRNAPMID:19770486
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