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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345615
Species: Homo sapiens
RGD Object: Gene
Symbol: OSR2
Name: odd-skipped related transciption factor 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OSR2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of OSR2 promoterPMID:27901495
OSR2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of OSR2 mRNAPMID:20106945 PMID:21632981 PMID:32234424
OSR2decreases expressionISOOsr2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of OSR2 mRNAPMID:20713471
OSR2multiple interactionsISOOsr2 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of OSR2 mRNA]PMID:22228805
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