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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343840
Species: Homo sapiens
RGD Object: Gene
Symbol: TMEM47
Name: transmembrane protein 47
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TMEM47affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of TMEM47 promoterPMID:27901495
TMEM47increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of TMEM47 3' UTR; Benzo(a)pyrene results in increased methylation of TMEM47 5' UTRPMID:27901495
TMEM47decreases expressionISOTmem47 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of TMEM47 mRNAPMID:21839799
TMEM47increases expressionISOTmem47 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of TMEM47 mRNAPMID:22228805 PMID:32417428
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