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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332081
Species: Mus musculus
RGD Object: Gene
Symbol: Disc1
Name: disrupted in schizophrenia 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Disc1decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of DISC1 intronPMID:27901495
Disc1affects methylationISODISC1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DISC1 intronPMID:30157460
Disc1decreases expressionISODISC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of DISC1 mRNAPMID:20064835 PMID:22316170 PMID:26238291
Disc1increases methylationISODISC1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of DISC1 3' UTRPMID:27901495
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