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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323765
Species: Mus musculus
RGD Object: Gene
Symbol: Axl
Name: AXL receptor tyrosine kinase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Axlmultiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to AXL promoter]PMID:19654925
Axlaffects methylationISOAXL (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of AXL exonPMID:30157460
Axldecreases methylationISOAXL (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of AXL promoterPMID:27901495
Axlincreases expressionISOAXL (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of AXL mRNAPMID:21632981 PMID:21871943 PMID:22316170 PMID:32234424
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