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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323203
Species: Mus musculus
RGD Object: Gene
Symbol: Cryz
Name: crystallin, zeta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cryzdecreases activityEXP 6480464CTDBenzo(a)pyrene results in decreased activity of CRYZ proteinPMID:29019276
Cryzincreases activityEXP 6480464CTDBenzo(a)pyrene results in increased activity of CRYZ proteinPMID:15297030
Cryzincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CRYZ mRNAPMID:15297030 PMID:22228805
Cryzmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CRYZ mRNA]; AHR protein promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]; carvacrol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CRYZ protein]; Copper inhibits the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]; Lead inhibits the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]PMID:15297030 PMID:22228805 PMID:29019276
Cryzdecreases expressionISOCRYZ (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CRYZ mRNAPMID:32234424
Cryzdecreases methylationISOCRYZ (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CRYZ promoterPMID:27901495
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