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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323175
Species: Mus musculus
RGD Object: Gene
Symbol: Dock2
Name: dedicator of cyto-kinesis 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dock2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of DOCK2 mRNAPMID:21569818 PMID:22610609
Dock2increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of DOCK2 intronPMID:27901495
Dock2decreases expressionISODOCK2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of DOCK2 mRNAPMID:20064835 PMID:20498004
Dock2increases methylationISODOCK2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of DOCK2 3' UTR; Benzo(a)pyrene results in increased methylation of DOCK2 promoterPMID:27901495
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