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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322123
Species: Homo sapiens
RGD Object: Gene
Symbol: SORL1
Name: sortilin related receptor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SORL1affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of SORL1 intronPMID:30157460
SORL1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SORL1 mRNAPMID:20106945 PMID:32234424
SORL1decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of SORL1 promoterPMID:27901495
SORL1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of SORL1 mRNAPMID:26238291
SORL1affects methylationISOSorl1 (Mus musculus)6480464CTDBenzo(a)pyrene affects the methylation of SORL1 intronPMID:27901495
SORL1increases expressionISOSorl1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SORL1 mRNAPMID:32417428
SORL1increases expressionISOSorl1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of SORL1 mRNAPMID:21839799
SORL1multiple interactionsISOSorl1 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SORL1 mRNA]PMID:22228805
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