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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319684
Species: Mus musculus
RGD Object: Gene
Symbol: Tm6sf2
Name: transmembrane 6 superfamily member 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tm6sf2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of TM6SF2 mRNAPMID:22228805
Tm6sf2multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to TM6SF2 promoter]PMID:19654925
Tm6sf2affects methylationISOTM6SF2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of TM6SF2 exonPMID:30157460
Tm6sf2decreases expressionISOTM6SF2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of TM6SF2 mRNAPMID:32234424
Tm6sf2increases methylationISOTM6SF2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of TM6SF2 exon; Benzo(a)pyrene results in increased methylation of TM6SF2 promoterPMID:27901495
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