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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319639
Species: Mus musculus
RGD Object: Gene
Symbol: Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sema3cmultiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SEMA3C mRNAPMID:27858113
Sema3cdecreases methylationISOSEMA3C (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SEMA3C promoterPMID:27901495
Sema3cincreases expressionISOSEMA3C (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SEMA3C mRNAPMID:32234424
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