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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318854
Species: Mus musculus
RGD Object: Gene
Symbol: Irak3
Name: interleukin-1 receptor-associated kinase 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irak3increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IRAK3 mRNAPMID:22228805
Irak3increases methylationISOIRAK3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of IRAK3 exon; Benzo(a)pyrene results in increased methylation of IRAK3 promoterPMID:27901495
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