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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317925
Species: Mus musculus
RGD Object: Gene
Symbol: Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pmepa1affects methylationISOPMEPA1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PMEPA1 5' UTRPMID:27901495
Pmepa1decreases expressionISOPmepa1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of PMEPA1 mRNAPMID:21839799
Pmepa1decreases methylationISOPMEPA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PMEPA1 promoterPMID:27901495
Pmepa1increases expressionISOPMEPA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PMEPA1 mRNAPMID:32234424
Pmepa1increases methylationISOPMEPA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PMEPA1 3' UTRPMID:27901495
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