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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315646
Species: Mus musculus
RGD Object: Gene
Symbol: Fermt1
Name: fermitin family member 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fermt1affects methylationISOFERMT1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FERMT1 intron; Benzo(a)pyrene affects the methylation of FERMT1 promoterPMID:30157460
Fermt1decreases expressionISOFERMT1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FERMT1 mRNAPMID:21714911
Fermt1decreases methylationISOFERMT1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of FERMT1 5' UTR; Benzo(a)pyrene results in decreased methylation of FERMT1 promoterPMID:27901495
Fermt1increases expressionISOFERMT1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of FERMT1 mRNAPMID:22316170
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