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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311555
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Usp28
Name: ubiquitin specific peptidase 28
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Usp28affects methylationISOUSP28 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of USP28 intronPMID:30157460
Usp28decreases expressionISOUsp28 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of USP28 mRNAPMID:22228805
Usp28decreases methylationISOUSP28 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of USP28 promoterPMID:27901495
Usp28increases mutagenesisISOUSP28 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of USP28 genePMID:25435355
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