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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311203
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ip1
Name: phosphoinositide-3-kinase interacting protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3ip1affects methylationISOPIK3IP1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PIK3IP1 exonPMID:27901495
Pik3ip1decreases expressionISOPIK3IP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PIK3IP1 mRNAPMID:22316170
Pik3ip1increases methylationISOPIK3IP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PIK3IP1 promoterPMID:27901495
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