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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311160
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nek7
Name: NIMA-related kinase 7
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13224726480464CTDBenzo(a)pyrene results in decreased expression of NEK7 mRNA

PMID:19770486
increases expressionISORGD:13224726480464CTDBenzo(a)pyrene results in increased expression of NEK7 mRNA

PMID:15034205
increases mutagenesisISORGD:13224716480464CTDBenzo(a)pyrene results in increased mutagenesis of NEK7 gene

PMID:25435355
multiple interactionsISORGD:13224726480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NEK7 mRNA]

PMID:15034205
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.