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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310999
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cadm1
Name: cell adhesion molecule 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cadm1affects methylationISOCADM1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CADM1 promoterPMID:27901495
Cadm1decreases expressionISOCADM1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CADM1 mRNAPMID:20106945 PMID:21632981 PMID:26238291
Cadm1decreases expressionISOCadm1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CADM1 mRNAPMID:19770486 PMID:22228805
Cadm1increases methylationISOCADM1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CADM1 5' UTR; Benzo(a)pyrene results in increased methylation of CADM1 exonPMID:27901495
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