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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310872
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tmprss13
Name: transmembrane serine protease 13
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tmprss13affects methylationISOTMPRSS13 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of TMPRSS13 exon; Benzo(a)pyrene affects the methylation of TMPRSS13 promoterPMID:27901495 PMID:30157460
Tmprss13decreases expressionISOTmprss13 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of TMPRSS13 mRNAPMID:22228805
Tmprss13decreases methylationISOTMPRSS13 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of TMPRSS13 5' UTRPMID:27901495
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