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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310595
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g4e
Name: phospholipase A2, group IVE
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pla2g4eaffects methylationISOPLA2G4E (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PLA2G4E promoterPMID:27901495
Pla2g4eincreases expressionISOPla2g4e (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PLA2G4E mRNAPMID:27195522
Pla2g4eincreases methylationISOPLA2G4E (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PLA2G4E exonPMID:27901495
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