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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Orai2
Name: ORAI calcium release-activated calcium modulator 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Orai2decreases methylationISOORAI2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ORAI2 5' UTRPMID:27901495
Orai2increases expressionISOORAI2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ORAI2 mRNAPMID:21632981
Orai2increases expressionISOOrai2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ORAI2 mRNAPMID:23735875
Orai2multiple interactionsISOOrai2 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to ORAI2 promoter]PMID:19654925
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