GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Orai2 | decreases methylation | ISO | ORAI2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of ORAI2 5' UTR | PMID:27901495 | Orai2 | increases expression | ISO | ORAI2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ORAI2 mRNA | PMID:21632981 | Orai2 | increases expression | ISO | Orai2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ORAI2 mRNA | PMID:23735875 | Orai2 | multiple interactions | ISO | Orai2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene promotes the reaction [AHR protein binds to ORAI2 promoter] | PMID:19654925 | |
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