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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309844
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pde6c
Name: phosphodiesterase 6C
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pde6caffects methylationISOPDE6C (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PDE6C promoterPMID:27901495
Pde6cincreases expressionISOPDE6C (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PDE6C mRNAPMID:21632981 PMID:21871943 PMID:22316170
Pde6cincreases methylationISOPDE6C (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PDE6C 5' UTRPMID:27901495
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