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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309837
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fli1
Name: Fli-1 proto-oncogene, ETS transcription factor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fli1affects methylationISOFLI1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FLI1 intronPMID:30157460
Fli1decreases expressionISOFLI1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FLI1 mRNAPMID:20064835
Fli1increases expressionISOFli1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of FLI1 mRNAPMID:32417428
Fli1increases methylationISOFLI1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of FLI1 3' UTR; Benzo(a)pyrene results in increased methylation of FLI1 promoterPMID:27901495
Fli1increases methylationISOFli1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of FLI1 intronPMID:27901495
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