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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa1
Name: nuclear receptor coactivator 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa1affects methylationISONCOA1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NCOA1 3' UTR; Benzo(a)pyrene affects the methylation of NCOA1 intronPMID:27901495 PMID:30157460
Ncoa1decreases expressionISONCOA1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NCOA1 mRNAPMID:20106945 PMID:21632981 PMID:22316170
Ncoa1decreases expressionISONcoa1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of NCOA1 mRNAPMID:19770486
Ncoa1decreases methylationISONcoa1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of NCOA1 intronPMID:27901495
Ncoa1increases expressionISONcoa1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of NCOA1 mRNAPMID:22228805
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