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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Larp6
Name: La ribonucleoprotein 6, translational regulator
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Larp6increases expressionISOLarp6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of LARP6 mRNAPMID:22228805
Larp6increases expressionISOLARP6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of LARP6 mRNAPMID:20064835 PMID:21632981 PMID:22316170
Larp6increases methylationISOLarp6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of LARP6 exon; Benzo(a)pyrene results in increased methylation of LARP6 intronPMID:27901495
Larp6increases methylationISOLARP6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of LARP6 promoterPMID:27901495
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