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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Uba7
Name: ubiquitin-like modifier activating enzyme 7
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Uba7affects methylationISOUBA7 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of UBA7 3' UTRPMID:27901495
Uba7decreases expressionISOUba7 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of UBA7 mRNAPMID:21569818
Uba7decreases methylationISOUBA7 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of UBA7 promoterPMID:27901495
Uba7multiple interactionsISOUba7 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to UBA7 promoter]PMID:19654925
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