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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307921
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldb2
Name: LIM domain binding 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldb2affects methylationISOLDB2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of LDB2 promoterPMID:27901495
Ldb2decreases expressionISOLDB2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of LDB2 mRNAPMID:20106945 PMID:32234424
Ldb2decreases expressionISOLdb2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of LDB2 mRNAPMID:27195522
Ldb2decreases methylationISOLDB2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of LDB2 exonPMID:27901495
Ldb2increases methylationISOLdb2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of LDB2 intronPMID:27901495
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