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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fcho1
Name: FCH and mu domain containing endocytic adaptor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fcho1affects methylationISOFCHO1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FCHO1 5' UTR; Benzo(a)pyrene affects the methylation of FCHO1 promoterPMID:27901495
Fcho1decreases expressionISOFcho1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of FCHO1 mRNAPMID:21569818
Fcho1increases methylationISOFCHO1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of FCHO1 3' UTRPMID:27901495
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