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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307594
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc46a3
Name: solute carrier family 46, member 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc46a3affects methylationISOSLC46A3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SLC46A3 promoterPMID:27901495
Slc46a3decreases expressionISOSLC46A3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SLC46A3 mRNAPMID:32234424
Slc46a3increases expressionISOSlc46a3 (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in increased expression of SLC46A3 mRNA; Benzo(a)pyrene results in increased expression of SLC46A3 mRNAPMID:19770486 PMID:21569818 PMID:32417428 PMID:32553695
Slc46a3multiple interactionsISOSlc46a3 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SLC46A3 mRNA; [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of SLC46A3 mRNAPMID:27858113 PMID:32553695
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