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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp39a1decreases expressionISOCYP39A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CYP39A1 mRNAPMID:32234424
Cyp39a1decreases expressionISOCyp39a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CYP39A1 mRNAPMID:19770486 PMID:22228805
Cyp39a1decreases methylationISOCyp39a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of CYP39A1 exon; Benzo(a)pyrene results in decreased methylation of CYP39A1 intronPMID:27901495
Cyp39a1increases expressionISOCYP39A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CYP39A1 mRNAPMID:16545412
Cyp39a1increases expressionISOCyp39a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CYP39A1 proteinPMID:34472326
Cyp39a1increases methylationISOCYP39A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CYP39A1 promoterPMID:27901495
Cyp39a1multiple interactionsISOCyp39a1 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CYP39A1 mRNA]PMID:22228805
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