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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306961
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arhgef15increases expressionISOArhgef15 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ARHGEF15 mRNAPMID:32417428
Arhgef15increases methylationISOARHGEF15 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ARHGEF15 3' UTRPMID:27901495
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