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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2
Name: nuclear factor, erythroid 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2decreases expressionISONFE2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NFE2 mRNAPMID:21871943 PMID:26238291
Nfe2increases expressionISONfe2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of NFE2 mRNAPMID:21964900 PMID:32417428
Nfe2multiple interactionsISONfe2 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NFE2 mRNAPMID:27858113
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