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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306529
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhcr24
Name: 24-dehydrocholesterol reductase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr24affects methylationISODHCR24 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DHCR24 promoterPMID:27901495
Dhcr24decreases expressionISODHCR24 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of DHCR24 mRNAPMID:20064835 PMID:26238291 PMID:32234424
Dhcr24increases expressionISODhcr24 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of DHCR24 mRNAPMID:20504355
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